Saptarshi Maji

Hello! I'm Saptarshi

'Researcher by profession, artist at heart' thats what I like to call my self. Science and art are not so different than each other, rather they are associated closely. While science seeks explanation for natural phenomena, art provides a subjective interpretation to it. By training, I am a molecular biologist who loves to uncover the mystries our life holds. I am currently working as a postdoctoral fellow at Prof. Bruno Antonny's lab in IPMC-CNRS, France. Besides being a researcher, I am an avid reader. In my leisure times, I write poetry and short stories in my mothertongue bengali. I am also passionate about photography, painting, playing guitar, and traveling.

Education

2018-2024

Research Scholar

Indian Institute of Science Education and Research (IISER) Kolkata

Department of Biological Sciences

2013-2018

Integrated BS-MS

Indian Institute of Science Education and Research (IISER) Kolkata

Masters in Biological Sciences, CGPA 8.09/10

2013

Higher Secondary

Nangi High School

From West Bengal Council of Higher Secondary Education (WBCHSE), scored 89% in science

2011

Secondary Level

Nangi High School

From West Bengal Board of Secondary Education (WBBSE), 95% in science

Experience

Research Experience

2024-Curr

Postdoctoral Research

Understanding the role of metal ions in skin barrier formation and skin immunity

Under the supervision of Prof. Bruno Antonny, Institut de pharmacologie moléculaire et cellulaire (IPMC), CNRS, France

2018-2024

PhD thesis

Functional and Temporal characterisation of Wilson Disease Protein ATP7B at the Lysosomes

Under the supervision of Dr. Arnab Gupta, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, India

2017-2018

Master Thesis

Regulatory mechanism of copper-transporters hCTR1 & ATP7B for maintaining copper homeostasis

Under the supervision of Dr. Arnab Gupta, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, India

Summer 2016

Summer Internship

Over-Expression and Purification of Recombinant PCBP2 Protein to Generate Antibody and Study Its Interaction with Coxsackie Virus B3 RNA

Under the supervision of Prof. Saumitra Das, Molecular and Cellular Biology, Indian Institute of Science (IISc) Bangalore, India

Summer 2015

Summer Internship

Survey of Endosymbiont Infection among Indian Arthropods

Under the supervision of Dr. Rhitoban RayChoudhury, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, India

Summer 2014

Summer Internship

Preventing Racemization of Chiral Schiff-base Ligands and Cu(II) Complexes in Solution to synthesize new architecture for chiral recognition

Under the supervision of Prof. Manabendra Ray, Department of Chemistry, Indian Institute of Technology (IIT) Guwahati, India

Skills

Laboratory skills

  • Animal cell culture
  • Genetic engineering
  • Super-resolution Microscopy
  • Cellular and Molecular Biology techniques
  • Lipid Biochemistry

Computation skills

  • ImageJ
  • R
  • PYTHON
  • LaTeX
  • MaxQuant
  • HTML

Communication skills

  • Conversationally fluent in English
  • Conversationally fluent in Hindi
  • Mother tongue Bengali

Publications

  1. Sharon Mary Jose*, Saptarshi Maji*, Mrittika Paul, Aayatti Mallick Gupta, Arnab Gupta; Comparative analysis of key Copper-ATPase domains sheds light on evolutionary divergence in human homologues ATP7A and ATP7B, (pre-print) (*equal contribution)
  2. Saptarshi Maji, Marinella Pirozzi, Ruturaj, Raviranjan Pandey, Tamal Ghosh, Santanu Das, Arnab Gupta; Copper-independent lysosomal localization of the Wilson disease protein ATP7B, Traffic (2023)
  3. Basudeb Mondal*, Abinash Padhy*, Saptarshi Maji*, Arnab Gupta, Sayam Sen Gupta; Dual stimuli-responsive cross-linked nanoassemblies from an amphiphilic mannose-6-phosphate based tri-block copolymer for lysosomal membrane permeabilization, Biomater. Sci. (2023) (*equal contribution)
  4. Sumanta Kar*, Samarpita Sen*, Saptarshi Maji, Deepashri Saraf, Ruturaj, Rupam Paul, Sohini Dutt, Basudeb Mondal, Enrique Rodriguez-Boulan, Ryan Schreiner, Durba Sengupta, Arnab Gupta; Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1, J. Biol. Chem. (2022) (*equal contribution)
  5. Santanu Das, Saptarshi Maji*, Ruturaj*, Indira Bhattacharya, Tanusree Saha, Nabanita Naskar, Arnab Gupta; Retromer retrieves the Wilson disease protein ATP7B from endolysosomes in a copper-dependent manner, J. Cell Sci. (2020) (*equal contribution)
  6. Taniya Mandal*, Sumanta Kar*, Saptarshi Maji*, Samarpita Sen*, Arnab Gupta; Structural and Functional Diversity Among the Members of CTR, the Membrane Copper Transporter Family, J. Membr. Biol. (2020) (*equal contribution)
  7. Raviranjan Pandey, Arpan Narayan Roy, Sandip Sarkar, Rakiba Rohman, Kaustav Chakraborty, Rupa Bargakshatriya, Sanjana Pandey, Pruthwiraj, Debosmita Bhattacharya, Saurav Kumar, Saptarshi Maji, Aidan T Pezacki, Sumit K Pramanik, Christopher J Chang, Ashima Bhattacharjee, Neelanjana Sengupta, Amitava Das, Arnab Gupta; Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agent, (pre-print)
  8. Subhendu Kumar Chatterjee*, Sumanta Kar*, Siddhanta Nikte*, Tisha Dash*, Saptarshi Maji, Tanmoy Ghosh, Durba Sengupta, Bidisha Sinha, Arnab Gupta; Structural and Functional Diversity Among the Members of CTR, the Membrane Copper Transporter Family, (pre-print) (*equal contribution)
  9. Rupam Paul, Adrija Chakrabarty, Suman Samanta, Swastika Dey, Raviranjan Pandey, Saptarshi Maji, Aidan T. Pezacki, Christopher J. Chang, Rupak Datta, Arnab Gupta; Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection, Commun. Biol. (2024)
  10. Ruturaj, Monalisa Mishra, Soumyendu Saha, Saptarshi Maji, Enrique Rodriguez-Boulan, Ryan Schreiner, Arnab Gupta; Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7B, J. Cell Sci. (2023)
  11. Kaustav Chakraborty, Santanu Das, Anusree Pal, Saptarshi Maji, Bhawana Rai, Arnab Gupta, Ashima Bhattacharjee; Wilson disease-causing mutations in the carboxyl terminus of ATP7B regulates its localization and Golgi exit selectively in the unpolarized cells, Metallomics (2023)
  12. Santanu Das, Ameena Mohammed, Taniya Mandal, Saptarshi Maji, Jay Verma, Ruturaj, Arnab Gupta; Polarized trafficking and copper transport activity of ATP7B: A mutational approach to establish genotype–phenotype correlation in Wilson disease, Hum. Mutat. (2022)
  13. Rupam Paul, Sourav Banerjee, Samarpita Sen, Pratiksha Dubey, Saptarshi Maji, Anand K Bachhawat, Rupak Datta, Arnab Gupta; A novel leishmanial copper P-type ATPase plays a vital role in parasite infection and intracellular survival, J. Biol. Chem. (2021)
  14. Moumita Maji, Sourav Acharya, Saptarshi Maji, Kallol Purkait, Arnab Gupta, Arindam Mukherjee; Differences in Stability, Cytotoxicity, and Mechanism of Action of Ru(II) and Pt(II) Complexes of a Bidentate N2O Donor Ligand, Inorg. Chem. (2020)

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